Pulmonary Vascular Remodeling in Pulmonary Hypertension Mice Aggravated by Hypothyroidism

Hypothyroidism exacerbates SuHx-induced PH by promoting PVR, inflammation, oxidative stress, and NF-κB pathway activation in mice. L-T4 supplementation alleviates these pathological changes. This study provides theoretical insights into the pathogenesis of hypothyroidism-related PH.