胰岛素抵抗
神经科学
能量稳态
中枢神经系统
信号
神经传递
胰岛素
平衡
突触可塑性
生物
胰岛素受体
能量代谢
内分泌学
细胞生物学
生物化学
受体
肥胖
摘要
The pathophysiological mechanisms intersecting metabolic and neurodegenerative disorders include insulin resistance, which has a strong involvement of environmental factors. Besides central regulation of whole-body homeostasis, insulin in the central nervous system controls molecular signalling that is critical for cognitive performance, namely signalling through pathways that modulate synaptic transmission and plasticity, and metabolism in neurons and astrocytes. This review provides an overview on how insulin signalling in the brain might regulate brain energy metabolism, and further identified molecular mechanisms by which brain insulin resistance might impair synaptic fuelling, and lead to cognitive deterioration.
科研通智能强力驱动
Strongly Powered by AbleSci AI