PI3K/AKT/mTOR通路
基因沉默
自噬
疾病
病态的
药理学
神经科学
脂多糖
医学
细胞
香料
化学
酪氨酸
细胞生物学
生物
组分(热力学)
钥匙(锁)
下调和上调
癌症研究
酪氨酸羟化酶
心理学
小RNA
上游(联网)
雷帕霉素的作用靶点
作者
Jiahui Jin,Xiran Li,Wang Yun-xi,Zhibo Yan,Airong Lv,Yanjun Zhang,Pengwei Zhuang,Hong Guo
标识
DOI:10.1021/acs.jafc.5c09022
摘要
6-Shogaol (6S), the major bioactive component of ginger, exhibits diverse pharmacological properties. This study investigated the therapeutic potential of 6S against α-synuclein (α-Syn), a key pathological marker in Parkinson's disease (PD), using an in vivo methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model and an in vitro lipopolysaccharide (LPS)-stimulated neuronal cell model. In vivo results showed that 6S significantly alleviated the behavioral deficits in PD mice, increased the count of tyrosine hydroxylase (TH)-positive neurons, and reduced α-Syn accumulation. Mechanistically, 6S exerted its effects by downregulating PI3K, p-Akt/Akt, and mTOR levels while upregulating LC3-II/LC3-I expression, thereby promoting autophagic activity. In vitro studies further confirmed that 6S directly interacted with the upstream protein VEGFR2, silencing VEGFR2-abrogated 6S-mediated inhibition of PI3K and α-Syn. Collectively, these findings highlight 6S as a promising functional food component for managing Parkinson's disease (PD) symptoms and targeting key pathological processes.
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