明胶
自愈水凝胶
生物相容性
环糊精
溶解度
化学
壳聚糖
抗菌活性
两亲性
抗菌剂
金黄色葡萄球菌
阿拉伯树胶
药物输送
组合化学
材料科学
有机化学
食品科学
细菌
聚合物
生物
共聚物
遗传学
作者
Aomei Zhang,Tingting Wang,Haibo Feng,Minghui Yang,Xingxing Jiang,Xiang Chen
摘要
Abstract Dihydromyricetin (DMY), a natural flavonoid compound, has garnered extensive research interests owing to its high pharmaceutical value with antioxidant, anticancer and antimicrobial properties. However, its intrinsic limitation of low water‐solubility and poor stability severely obstructs its biomedical applications. Herein, a dynamic imine cross‐linking strategy to assemble DMY/DA‐β‐CD/gelatin hydrogel (DDG) is reported, with the aim of enhancing DMY bio‐efficacy and achieve a synergistic antibacterial effect. DMY can be wrapped by the amphiphilic dialdehyde‐β‐cyclodextrin (DA‐β‐CD) to form an inclusion compound (DMY/DA‐β‐CD), significantly increasing its water‐solubility without compromising its sustainable release. Furthermore, the Schiff base reaction between DA‐β‐CD and gelatin drive the formation of DDG hydrogel featuring viscoelastic, self‐healing and injectability properties, serving as a DMY delivery platform. DMY and DA‐β‐CD synergistically inhibited bacterial proliferation, enabling a broad‐spectrum antibacterial effect against Escherichia coli and Staphylococcus aureus with over 90% inhibition and good biocompatibility. Our work provides a paradigm for self‐assembling DMY inclusion compound into a hydrogel to improve the bio‐efficacy of DMY, so that the hydrogel can be used as a carrier for hydrophobic drug delivery with promising applications in the biomedical field.
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