抗菌活性
铜绿假单胞菌
群集运动
代谢组学
金黄色葡萄球菌
转录组
化学
抗生素
微生物学
细菌
三氯生
生物
生物膜
生物化学
基因
群体感应
基因表达
生物信息学
遗传学
病理
医学
作者
Wee Han Poh,Nur Syahirah Ruhazat,Lay Kien Yang,Devendra Shivhare,Peng Ken Lim,K. Yoganathan,Scott A. Rice,Marek Mutwil
标识
DOI:10.3389/fpls.2023.1205725
摘要
Antibacterial resistance poses a significant global threat, necessitating the discovery of new therapeutic agents. Plants are a valuable source of secondary metabolites with demonstrated anticancer and antibacterial properties. In this study, we reveal that Melastoma dodecandrum exhibits both bacteriostatic and bactericidal effects against Pseudomonas aeruginosa and Staphylococcus aureus . Treatment with plant extracts results in membrane damage and a reduction in P.aeruginosa swimming and swarming motility. A comparative analysis of bacterial transcriptomes exposed to M.dodecandrum extracts and four distinct antibiotics indicates that the extracts may trigger similar transcriptomic responses as triclosan, a fatty acid synthesis inhibitor. Activity-guided fractionation suggests that the antibacterial activity is not attributable to hydrolyzable tannins, but to unidentified minor compounds. Additionally, we identified 104 specialized metabolic pathways and demonstrated a high level of transcriptional coordination between these biosynthetic pathways and phytohormones, highlighting potential regulatory mechanisms of antibacterial metabolites in M.dodecandrum.
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