葡萄膜炎
炎症
药理学
促炎细胞因子
活性氧
生物利用度
医学
免疫学
化学
生物化学
作者
Xinyu Li,Zhongxing Chen,Jieyi Bai,Xin Li,Xin Chen,Zheng Li,Hongxian Pan,Siheng Li,Qingzhu Gao,Nan Zhao,Aodong Chen,Huilin Xu,Yufeng Wen,Lan Du,Mu Yang,Xingtao Zhou,Jinhai Huang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-10-27
卷期号:17 (24): 25377-25390
标识
DOI:10.1021/acsnano.3c08869
摘要
Uveitis is a complex ocular inflammatory disease with a multifactorial etiology that can result in blindness. Although corticosteroid eye drops are the primary treatment for anterior uveitis, their efficacy is limited by low bioavailability, adverse effects, and a narrow focus on inflammation. In this study, the multifunctional hydrogel eye drops (designated as DCFH) were developed by incorporating the anti-inflammatory agent dexamethasone (DSP) and reactive oxygen species (ROS) scavenger cerium-based metal–organic frameworks (Ce-MOFs) into thermosensitive triblock copolymer F127 for the synergistic treatment against uveitis. The resulting F127 eye drops offer a favorable alternative to ophthalmic solution due to its thermosensitivity, thixotropy, light transmittance, improved ocular bioavailability, and unexpected anti-inflammatory efficacy. Notably, the participation of nanoporous Ce-MOFs, functional drug carriers, not only reduces ROS level but also boosts the anti-inflammatory activity of DSP in vitro. Therapeutically, the multifunctional DCFH exhibits superior efficacy in treating endotoxin-induced uveitis by mitigating the ophthalmic inflammatory reaction, suppressing inflammatory cytokines (e.g., TNF-α, IL-6, and IL-17) and downregulating the expression of iNOS and NLPR3. This synergistic treatment provides a valuable and promising approach for the management of uveitis and other ocular inflammatory conditions.
科研通智能强力驱动
Strongly Powered by AbleSci AI