医学
接收机工作特性
胎龄
前瞻性队列研究
脑室出血
心脏病学
内科学
肺动脉
怀孕
遗传学
生物
作者
Sandra Terroba‐Seara,Ignacio Oulego-Erróz,Daniel Palanca Arias,Zenaida Galve-Pradel,Sara Delgado-Nicolás,Alicia Pérez-Pérez,Jorge Rodríguez-Ozcoidi,Ana Lavilla-Oíz,María Carmen Bravo,Leticia La Banda-Montalvo,Paula Méndez‐Abad,Pamela Zafra‐Rodríguez,Lorena Rodeño Fernández,Jon Montero‐Gato,Carmen Bustamante-Hervás,Cristina Vega-Del-Val,Javier Rodríguez‐Fanjul,Juan Mayordomo‐Colunga,Iosune Alegría-Echauri
标识
DOI:10.1136/archdischild-2024-327196
摘要
Objectives (1) To assess how main pulmonary artery peak Doppler velocity (MPAVpeak) correlates with right ventricular output (RVO) and superior vena cava flow (SVCf), (2) to assess the reproducibility of MPAVpeak and (3) to test the prognostic accuracy of MPAVpeak to predict high-grade intraventricular haemorrhage (IVH) or death at seventh day of life. Design Prospective cohort study. Setting Nine third-level neonatal units in Spain. Patients Preterm infants <33 weeks of gestational age who had standardised measurements of MPAVpeak, RVO and SVCf at 6, 12 and 24 hours of life. Main outcome measures High-grade IVH or death at seventh day of life. Results One hundred and ninety preterm infants with a median (IQR) gestational age and birth weight of 29.7 weeks (27.1–31.8) and 1152 g (892–1491), respectively, were included. High-grade IVH or death at seventh day of life occurred in 24 (12.6%). MPAVpeak was strongly correlated with RVO (Spearman rho 0.826–0.843). MPAVpeak discriminated well for low RVO (<120 mL/kg/min) at 6 (AUROC, area under the receiver operating characteristic curve=0.90), 12 (AUROC 0.94) and 24 hours (AUROC 0.86). Observer reproducibility was better for MPAVpeak (inter-observer limits of agreement ±8.4%) compared with RVO (±18.8%) and SVCf (±32.2%). The prognostic accuracy of MPAVpeak to predict high-grade IVH or death was good (AUROC >0.75) and non-inferior to RVO and SVCf (DeLong’s test p>0.05). Conclusions MPAVpeak is an adequate marker of systemic blood flow with high reproducibility and acceptable prognostic accuracy in preterm infants below 33 weeks of gestational age during the first day of life.
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