化学
化学选择性
催化作用
酰胺
芳基
丙二酸
组合化学
氧化还原
还原消去
镍
过渡金属
小学(天文学)
有机化学
烷基
天文
物理
作者
Alexis L. Gabbey,Nicholas W. M. Michel,Joseph V. Hughes,Louis‐Charles Campeau,Sophie Rousseaux
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-04-26
卷期号:24 (17): 3173-3178
被引量:8
标识
DOI:10.1021/acs.orglett.2c00918
摘要
The transition-metal-catalyzed α-arylation of secondary amides remains a synthetic challenge due to the presence of a free N-H bond. We report a strategy to synthesize secondary α-aryl amides via a Ni-catalyzed reductive arylation of redox-active N-hydroxyphthalimide (NHP) esters of malonic acid half amides. This transformation proceeds under mild conditions and displays excellent chemoselectivity for amide α-arylation in the presence of other enolizable carbonyls. The NHP ester substrates are readily prepared from Meldrum's acid.
科研通智能强力驱动
Strongly Powered by AbleSci AI