LncRNA CPhar mediates exercise-induced cardioprotection by promoting eNOS phosphorylation at Ser1177 via DDX17/PI3K/Akt pathway after MI/RI

We have read an interesting paper entitled “Exercise-induced late preconditioning in mice is triggered by eNOS-dependent generation of nitric oxide and activation of PKCε and is mediated by increased iNOS activity” written by Guo and his colleagues [1]. They investigated the protective role of exercise against myocardial infarction and found that exercise-induced late preconditioning depends on the phosphorylation status of eNOS at Ser1177 and subsequent NO generation and PKCε activation. Phosphorylation of eNOS-Ser(1177) is a critical event for eNOS activation, which was reported to be associated with morphometric improvement of cardiac hypertrophy and function recovery [2].