PLGA公司
罗哌卡因
材料科学
差示扫描量热法
挤压
扫描电子显微镜
生物医学工程
药物输送
傅里叶变换红外光谱
体内
粒径
微粒
丙交酯
化学工程
色谱法
纳米技术
化学
聚合物
纳米颗粒
药理学
共聚物
复合材料
医学
物理
生物技术
生物
工程类
热力学
作者
Shih-Jyun Shen,Ying‐Chao Chou,Shih‐Chieh Hsu,Yu‐Ting Lin,Chia Jung Lu,Shih‐Jung Liu
出处
期刊:Polymers
[MDPI AG]
日期:2022-02-11
卷期号:14 (4): 702-702
被引量:2
标识
DOI:10.3390/polym14040702
摘要
Microencapsulation plays an important role in biomedical technology owing to its particular and attractive characteristics. In this work, we developed ropivacaine and dexamethasone loaded poly(D, L-lactide-co-glycolide) (PLGA) microparticles via electrospraying technique and investigated the release behavior of electrosprayed microparticles. The particle morphology of sprayed particles was assessed using scanning electron microscopy (SEM). The in vitro drug release kinetics were evaluated employing an elution method, and the in vivo pharmaceutical release as well as its efficacy on pain relief were tested using an animal activity model. The microscopic observation suggested that sprayed microparticles exhibit a size distribution of 5-6 µm. Fourier-transform infrared spectrometry and differential scanning calorimetry demonstrated the successful incorporation of pharmaceuticals in the PLGA particulates. The drugs-loaded particles discharged sustainably high concentrations of ropivacaine and dexamethasone at the target region in vivo for over two weeks, and the drug levels in the blood remained low. By adopting the electrospraying technique, we were able to prepare drug-embedded polymeric microparticles with effectiveness and with a sustainable capability for postoperative pain control.
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