四甲基铵
氟化物
亲核细胞
溶剂化
试剂
化学
反应性(心理学)
组合化学
亲核芳香族取代
亲核取代
有机化学
作者
Vladimir Iashin,Tom Wirtanen,Jesus E. Perea‐Buceta
出处
期刊:Catalysts
[MDPI AG]
日期:2022-02-18
卷期号:12 (2): 233-233
被引量:1
标识
DOI:10.3390/catal12020233
摘要
Nucleophilic ionic sources of fluoride are essential reagents in the synthetic toolbox to access high added-value fluorinated building blocks unattainable by other means. In this review, we provide a concise description and rationale of the outstanding features of one of these reagents, tetramethylammonium fluoride (TMAF), as well as disclosing the different methods for its preparation, and how its physicochemical properties and solvation effects in different solvents are intimately associated with its reactivity. Furthermore, herein we also comprehensively describe its historic and recent utilization, up to December 2021, in C-F bond-forming reactions with special emphasis on nucleophilic aromatic substitution fluorinations with a potential sustainable application in industrial settings, as well as its use as a base capable of rendering unprecedented transformations.
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