医学
怀孕
不利影响
胎盘
流行病学
动物研究
胎儿
生理学
产科
炎症
疾病
重症监护医学
内科学
生物
遗传学
作者
Biyang Xu,Yiping W. Han
摘要
Abstract The link between oral health and adverse pregnancy outcomes has been suggested by numerous epidemiological studies. More recent studies indicate the relationship between severity of periodontal disease and adverse pregnancy outcomes. Two virulence mechanisms are proposed: direct invasion of oral microorganisms or their components into the fetal‐placenta unit and inflammatory mediators produced in the oral cavity affecting the fetal‐placenta unit. While interventional periodontal therapy still yielded contradictory results, animal studies suggest that maternal supplementation of omega‐3 fatty acids protects the fetus by suppressing inflammation as well as bacteria proliferation in the placenta. This article reviews the recent epidemiological, mechanistic, interventional, and therapeutic studies of oral health and adverse pregnancy outcomes.
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