脂多糖
化学
查尔酮
一氧化氮合酶
肿瘤坏死因子α
小胶质细胞
一氧化氮
消炎药
药理学
巨噬细胞
前列腺素E2
环氧合酶
生物化学
神经炎症
NF-κB
类黄酮
炎症
立体化学
酶
生物
免疫学
体外
信号转导
抗氧化剂
内分泌学
有机化学
作者
Chi-Su Yoon,Hwan Mo Lee,Zhiming Liu,Hyeong-Kyu Lee,Dong-Sung Lee
摘要
Lindera erythrocarpa contains various constituents such as cyclopentenedione-, flavonoid-, and chalcone-type components. In this study, a novel bi-linderone derivative and 17 known compounds were isolated from the leaves of L. erythrocarpa by using various chromatographic methods. The structures of the components were determined from nuclear magnetic resonance and mass spectrometry data. All isolated compounds were tested for anti-inflammatory and anti-neuroinflammatory activities in lipopolysaccharide (LPS)-induced BV2 and RAW264.7 cells. Some of these compounds showed anti-inflammatory effects by inhibiting the nitric oxide (NO) produced by LPS. In particular, linderaspirone A (16), bi-linderone (17) and novel compound demethoxy-bi-linderone (18) showed significant inhibitory effects on the production of prostaglandin E2 (PGE2), tumor necrosis factor-α, and interleukin-6. The three compounds also inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), which are pro-inflammatory proteins, and the activation of nuclear factor κB (NF-κB). Therefore, linderaspirone A (16), bi-linderone (17), and demethoxy-bi-linderone (18) isolated from the leaves of L. erythrocarpa have therapeutic potential in neuroinflammatory diseases.
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