纳米医学
药物输送
脚手架
免疫系统
归巢(生物学)
材料科学
巨噬细胞极化
巨噬细胞
药品
体内
纳米技术
炎症
生物医学工程
体外
生物
药理学
免疫学
医学
纳米颗粒
生物技术
生物化学
生态学
作者
Min He,Qian Wang,Yunbo Feng,Xinghui Gao,Chao He,Jiangge Li,Weifeng Zhao,Weidong Tian,Changsheng Zhao
标识
DOI:10.1021/acsami.1c20809
摘要
Implanted bone scaffolds or their biodegradation products may disturb the sequential functions of distinct macrophage phenotypes and cause improper timing of macrophage activation, resulting in delayed or dysfunctional bone regeneration. Although spatiotemporal manipulation of the immune response has been recognized as a promising strategy to address this issue, developing satisfactory drug delivery systems with the function of proper timing control on the macrophage phenotype transformation from pro-inflammatory M1 to anti-inflammatory M2 phenotype still remains a challenge. Here, we propose an amphiphilic nanomedicine with dual anti-inflammatory functions and inflammation-responsive drug release properties to spatiotemporally manage the osteoimmunomodulation of the bone scaffold. The nanomedicine enables the modified scaffold to manipulate the immune response in a staged manner, not only avoiding the overinhibition of M1 macrophages in the initial phase but also facilitating its polarization to M2 phenotype, as well as exhibiting full-course inhibition on later biodegradation-induced inflammation. The described immunomodulatory manner attempts to conform to the principle of osteoimmunomodulation, consequently resulting in better in vivo osteogenesis compared with traditional drug delivery systems. We anticipate that this strategy might aid the development of advanced immunomodulatory bone biomaterials.
科研通智能强力驱动
Strongly Powered by AbleSci AI