Surface functionalization of Titania Nanotubes arrays and vancomycin controlled release using Silk Fibroin Nanofibers coating

Bacterial infections are the leading cause of failure in surgeries based on orthopedic implants. One of the promising methods to suppress bacterial infection, given the high efficiency of antibiotic administration, is to use Titania Nanotubes (Titania-NTs) loaded with antibiotics. Titania-NTs obtained by the electrochemical anodizing process have presented a modern approach in drug delivery applications. However, it is complicated to control the drug release process from drug delivery systems. This study investigates the controlled release of Vancomycin (V) from Titania-NTs surfaces enriched by drugs via physical absorption. Titania-NTs loaded with Vancomycin were coated by Silk Fibroin Nanofibers (SF-NFs). The results showed that the drug delivery was controlled through a coated layer of nanofibers. Moreover, Vancomycin inhibits bacterial development due to its antibacterial property. This is a feasible method, which enhances the viability of cells. Therefore, loading Titania-NTs with Vancomycin and using SF-NFs, as a high potential coating, can be an effective method to decrease infections after implanting orthopedic biomaterials. Drug release kinetics were calculated using different kinetic models and coefficient of determination (R2) for each model.