神经病理学
医学
血管内皮生长因子
病理
痴呆
生物标志物
优势比
内科学
β淀粉样蛋白
阿尔茨海默病
病态的
疾病
正电子发射断层摄影术
队列
血管性痴呆
肿瘤科
核医学
血管内皮生长因子受体
生物
生物化学
作者
Zachary Winder,Tiffany L. Sudduth,Sonya Anderson,Ela Patel,Janna H. Neltner,Barbara J. Martin,Katherine E. Snyder,Erin L. Abner,Gregory A. Jicha,Peter T. Nelson,Donna M. Wilcock
摘要
Abstract Introduction Clinically, detection of disease‐causing pathology associated with Alzheimer's disease (AD) and vascular contributions to cognitive impairment and dementia (VCID) is limited to magnetic resonance imaging and positron emission tomography scans, which are expensive and not widely accessible. Here, we assess angiogenic, inflammatory, and AD‐related plasma biomarkers to determine their relationships with human post mortem neuropathology. Method Plasma samples were analyzed using a digital immunoassay and pathological evaluation was performed by University of Kentucky Alzheimer's Disease Research Center neuropathologists. The association of plasma markers with neuropathology was estimated via proportional odds and logistic regressions adjusted for age. Results Included cases (N = 90) showed increased tau/amyloid beta (Aβ)42 ratio, glial fibrillary acidic protein (GFAP), vascular endothelial growth factor A (VEGF‐A), and placental growth factor (PlGF) were positively associated with higher level of AD neuropathological change, while higher Aβ42/Aβ40 ratio was inversely associated. Higher PlGF, VEGF‐A, and interleukin 6 were inversely associated with chronic cerebrovascular disease, while Aβ42/Aβ40 ratio was positively associated. Discussion Our results provide support for the continued study of plasma biomarkers as a clinical screening tool for AD and VCID pathology.
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