医学
类风湿性关节炎
常见可变免疫缺陷
干燥综合征
免疫学
皮肤病科
类风湿因子
舍格伦综合征
关节炎
内科学
疾病
作者
Li Hsin Lin,Chih Neng Tsai,Ming Fei Liu,Chrong-Reen Wang
摘要
Several autoimmune diseases have been reported to be associated with common variable immunodeficiency disease (CVID), including rheumatoid arthritis and Sjogren's syndrome. On the other hand, approximately 20-30% of patients with rheumatoid arthritis develop secondary Sjogren's syndrome. A 26-year-old woman had a 6-year history of chronic symmetric polyarthritis and 3-year history of sicca syndrome prior to admission for pneumonia. Rheumatoid arthritis with secondary Sjogren's syndrome had been diagnosed 1 year before. The patient had experienced 3 episodes of pneumonia during the previous 3 years. Markedly depressed serum immunoglobulin levels prompted a suspicion of common variable immunodeficiency, and the impression was confirmed after a series of examinations. Monthly administration of intravenous immunoglobulin (IVIG) alleviated the polyarthritis and improved the sicca syndrome. IVIG replacement therapy was ultimately successful in curing recurrent bacterial infections, chronic polyarthritis, and improving the severity of sicca syndrome.
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