固体脂质纳米粒
Zeta电位
胰岛素
口服
吸收(声学)
材料科学
纳米颗粒
粒径
溶剂
药理学
色谱法
医学
化学
内科学
纳米技术
生物化学
复合材料
物理化学
作者
Bruno Sarmento,Susana Martins,Domingos Ferreira,Eliana B. Souto
出处
期刊:PubMed
日期:2007-01-01
被引量:48
摘要
The aim of this work was to produce and characterize cetyl palmitate-based solid lipid nanoparticles (SLN) containing insulin, and to evaluate the potential of these colloidal carriers for oral administration. SLN were prepared by a modified solvent emulsification-evaporation method based on a w/o/w double emulsion. The particle size, zeta potential and association efficiency of unloaded and insulin-loaded SLN were determined and were found to be around 350 nm, negatively charged and the insulin association efficiency was over 43%. After oral administration of insulin-loaded SLN to diabetic rats, a considerable hypoglycemic effect was observed during 24 hours. These results demonstrated that SLN promote the oral absorption of insulin.
科研通智能强力驱动
Strongly Powered by AbleSci AI