Lv41
660 积分 2023-07-18 加入
Discovery of GSI526: a potent IRAK4-targeting PROTAC degrader with efficient degradation and suppression of inflammatory signaling
8小时前
已完结
Design, Synthesis, and Evaluation of Nucleolin-Bridged, MDM2-Recruiting IRAK4 Degraders for the Treatment of Autoimmune Diseases
8小时前
已完结
Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis
1个月前
已完结
Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy
2个月前
已完结
Potent and isoform-selective PARP1 degraders for the treatment of BRCA-deficient cancers
2个月前
已完结
Potent and isoform-selective PARP1 degraders for the treatment of BRCA-deficient cancers
3个月前
已完结
Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera
3个月前
已完结
Development of APH003─a Highly Potent, Selective, and Orally Bioavailable IRAK4 PROTAC Degrader for the Treatment of Inflammatory Diseases
3个月前
已关闭
Misconceptions among medicinal chemists regarding ADME and PK optimization
5个月前
已完结
文献求助
6个月前
已完结
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