孟德尔随机化
随意的
机制(生物学)
计算生物学
银屑病
孟德尔遗传
癌症
遗传学
生物信息学
生物
医学
基因
基因型
遗传变异
免疫学
哲学
材料科学
认识论
复合材料
作者
Maya Ran,Ou Sha,Kin Yip Tam
标识
DOI:10.1016/j.compbiolchem.2024.108089
摘要
Psoriasis (Ps), a chronic inflammatory disease affecting approximately 2 % of the global population, has been associated with an increased risk of liver cancer in observational studies. However, their causal relationships as well as underlying shared molecular mechanisms between Ps and liver cancer remain unclear. Using bidirectional Mendelian randomization analysis, we revealed that a genetic predisposition to liver cancer increased the risk of Ps in European and East Asian populations but not the other way around. Moreover, we analyzed three transcriptomic datasets of patients with Ps and liver cancer from open-source databases. Differentially expressed genes (DEGs) and disease-specific gene co-expression module analyses revealed that cell-cycle dysregulation was the shared mechanism of Ps and liver cancer. Moreover, we identified a rank-conservative gene signature shared between these two diseases, which demonstrated significance in diagnostic and prognostic predictions. These findings provided valuable insights into the interconnections between Ps and liver cancer, which may be helpful to guide therapeutic management.
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