神经发生
Notch信号通路
神经科学
纹状体
生物
槽口1
星形胶质细胞
薄壁组织
Hes3信号轴
冲程(发动机)
大脑皮层
信号转导
中枢神经系统
细胞生物学
多巴胺
工程类
机械工程
植物
作者
Jens P Magnusson,Christian Göritz,Jemal Tatarishvili,David O. Dias,Emma Smith,Olle Lindvall,Zaal Kokaia,Jonas Frisén
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2014-10-10
卷期号:346 (6206): 237-241
被引量:361
标识
DOI:10.1126/science.346.6206.237
摘要
Neurogenesis is restricted in the adult mammalian brain; most neurons are neither exchanged during normal life nor replaced in pathological situations. We report that stroke elicits a latent neurogenic program in striatal astrocytes in mice. Notch1 signaling is reduced in astrocytes after stroke, and attenuated Notch1 signaling is necessary for neurogenesis by striatal astrocytes. Blocking Notch signaling triggers astrocytes in the striatum and the medial cortex to enter a neurogenic program, even in the absence of stroke, resulting in 850 ± 210 (mean ± SEM) new neurons in a mouse striatum. Thus, under Notch signaling regulation, astrocytes in the adult mouse brain parenchyma carry a latent neurogenic program that may potentially be useful for neuronal replacement strategies.
科研通智能强力驱动
Strongly Powered by AbleSci AI