PI3K/AKT/mTOR通路
子宫内膜异位症
安普克
活性氧
氧化应激
炎症
线粒体
医学
内分泌学
发病机制
癌症研究
内科学
信号转导
生物
细胞生物学
激酶
蛋白激酶A
作者
Lama Assaf,Assaad A. Eid,Joseph Nassif
出处
期刊:Life Sciences
[Elsevier]
日期:2022-10-01
卷期号:306: 120805-120805
被引量:20
标识
DOI:10.1016/j.lfs.2022.120805
摘要
Endometriosis is the presence of endometrial tissue outside the uterine cavity usually in the ovaries, fallopian tube, and pelvic cavity. It's a chronic enigmatic gynecological condition associated with dysmenorrhea, dyspareunia, pelvic pain, and infertility. Endometriosis lesions exist in a unique microenvironment characterized by increased concentrations of hormones, inflammation, and oxidative stress. This environment promotes cell survival through the binding of membrane receptors and subsequent cascading activation of intracellular kinases that stimulate a cellular response. In endometriosis, well-established signaling pathways, mTOR and AMPK, are altered via steroid hormones and other factors to promote cell growth, migration, and proliferation. This is accompanied by dysfunction in the mitochondria that increase energy production to sustain proliferation demands consequently leading to reactive oxygen species overproduction. This review aims to summarize the role of altered mTOR/AMPK signaling pathway, mitochondrial dysfunction, and reactive oxygen species overproduction along with providing therapeutic and diagnostic approaches. Highlighting these factors would provide a better understanding to reach a coherent theory for the pathogenesis of endometriosis.
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