Autophagy inhibitors 3-MA and LY294002 repress osteoclastogenesis and titanium particle-stimulated osteolysis

In this study, we found autophagy inhibitors 3-MA and LY294002 reduced osteoclast differentiation and osteoclast-related genes in vitro. In vivo, 3-MA and LY294002 repressed titanium particle-stimulated inflammatory osteolysis and osteoclastogenesis.