纳米医学
紫杉醇
光热治疗
壳聚糖
体内
乳腺癌
转移
化学
癌症研究
癌细胞
药理学
癌症
纳米技术
材料科学
医学
纳米颗粒
内科学
生物
生物化学
生物技术
作者
Pei Wang,Zhi Peng,Yanyan Zhang,Xintong Zhang,Xia Chen,Louzhen Fan,Bo Zhi Chen,Shiwei Niu,Kaili Du,Li‐Min Zhu
标识
DOI:10.1016/j.carbpol.2024.122073
摘要
Breast cancer remains one of the most intractable diseases, especially the malignant form of metastasis, with which the cancer cells are hard to track and eliminate. Herein, the common known carbohydrate polymer chitosan (CS) was innovatively used as a shelter for the potent tumor-killing agent. The designed nanoparticles (NPs) not only enhance the solubility of hydrophobic paclitaxel (PTX), but also provide a "hide" effect for cytotoxic PTX in physiological condition. Moreover, coupled with the photothermal (PTT) properties of MoS2, results in a potent chemo/PTT platform. The MoS2@PTX-CS-K237 NPs have a uniform size (135 ± 17 nm), potent photothermal properties (η = 31.5 %), and environment-responsive (low pH, hypoxia) and near infrared (NIR) laser irradiation-triggered PTX release. Through a series of in vitro and in vivo experiments, the MoS2@PTX-CS-K237 showed high affinity and specificity for breast cancer cells, impressive tumor killing capacity, as well as the effective inhibitory effect of metastasis. Benefit from the unique optical properties of MoS2, this multifunctional nanomedicine also exhibited favorable thermal/PA/CT multimodality imaging effect on tumor-bearing mice. The system developed in this work represents the advanced design concept of hierarchical stimulus responsive drug release, and merits further investigation as a potential nanotheranostic platform for clinical translation.
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