炎症性肠病
医学
重症监护医学
中毒性巨结肠
腹泻
疾病
临床试验
腹痛
生物信息学
溃疡性结肠炎
病理
内科学
生物
作者
Fabiana Andréa Moura,Kívia Queiroz de Andrade,Juliana Cardoso dos Santos,Orlando Luiz de Araújo,Marília O. F. Goulart
出处
期刊:Redox biology
[Elsevier]
日期:2015-12-01
卷期号:6: 617-639
被引量:233
标识
DOI:10.1016/j.redox.2015.10.006
摘要
Oxidative stress (OS) is considered as one of the etiologic factors involved in several signals and symptoms of inflammatory bowel diseases (IBD) that include diarrhea, toxic megacolon and abdominal pain. This systematic review discusses approaches, challenges and perspectives into the use of nontraditional antioxidant therapy on IBD, including natural and synthetic compounds in both human and animal models. One hundred and thirty four papers were identified, of which only four were evaluated in humans. Some of the challenges identified in this review can shed light on this fact: lack of standardization of OS biomarkers, absence of safety data and clinical trials for the chemicals and biological molecules, as well as the fact that most of the compounds were not repeatedly tested in several situations, including acute and chronic colitis. This review hopes to stimulate researchers to become more involved in this fruitful area, to warrant investigation of novel, alternative and efficacious antioxidant-based therapies.
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