表观遗传学
生物
癌症
癌症研究
细胞周期
细胞生长
基因
癌变
发病机制
抑制器
细胞凋亡
细胞
遗传学
免疫学
作者
Hilmar Berger,Miguel Sardinha Marques,Rieke Zietlow,Thomas F. Meyer,José Carlos Machado,Céu Figueiredo
出处
期刊:Helicobacter
[Wiley]
日期:2016-08-16
卷期号:21 (S1): 34-38
被引量:46
摘要
Abstract Gastric cancer ( GC ) results from a multistep process that is influenced by Helicobacter pylori infection, genetic susceptibility of the host, as well as of other environmental factors. GC results from the accumulation of numerous genetic and epigenetic alterations in oncogenes and tumor suppressor genes, leading to dysregulation of multiple signaling pathways, which disrupt the cell cycle and the balance between cell proliferation and cell death. For this special issue, we have selected to review last year's advances related to three main topics: the cell of origin that initiates malignant growth in GC , the mechanisms of direct genotoxicity induced by H. pylori infection, and the role of aberrantly expressed long noncoding RNA s in GC transformation. The understanding of the molecular basis of GC development is of utmost importance for the identification of novel targets for GC prevention and treatment.
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