硒
锌
癫痫
神经学
胃肠病学
内科学
医学
显著性差异
内分泌学
化学
精神科
有机化学
作者
Heidar Farahani,Alireza R. Ashthiani,Mher Sardari Masihi
出处
期刊:PubMed
日期:2013-04-01
卷期号:18 (2): 138-42
被引量:10
摘要
To estimate serum zinc and selenium levels in a group of healthy subjects and correlate these with epileptic patients.This case-control study was conducted in the Department of Neurology, Valiasr Hospital, Iran, between November 2011 and May 2012 on 40 patients aged 26.63+/-5.78 years who were diagnosed with generalized and a single epileptic form of epilepsy by a neurologist for the first time. The control group was selected from healthy individuals, and matched to the case group. Serum zinc was measured by the calorimetric method using a Randox kit. Selenium was measured by atomic absorption spectroscopy.The mean zinc level was 151.2+/-29.75 ug/dl in the cases, and 181.63+/-60.19 ug/dl in the controls (p=0.006). The mean selenium level was 73.37+/-13.31 ug/l in cases compared with 85.55+/-19.39 ug/dl in controls (p=0.002). We also found a significant difference between the selenium levels by gender in the 2 groups (p=0.03).We observed statistically significant changes in serum zinc and selenium levels of epileptic adult patients in comparison with the control group. As zinc and selenium are used as potent antioxidants in cellular interactions, changes in their serum values may result in enzymatic changes, which in turn can cause neurological disorders.
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