| 标题 |
Suppression of response to foreign substances by intestinal macrophages
肠道巨噬细胞对外来物质应答的抑制作用
相关领域
脂多糖
巨噬细胞
TLR4型
细胞生物学
CD14型
炎症性肠病
免疫学
功能（生物学）
生物
平衡
微生物学
信号转导
免疫系统
医学
疾病
病理
体外
生物化学
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Abstract Macrophages play an important role in the maintenance of homeostasis by changing their function according to the tissue and environment everywhere in the body. We have proposed that intestinal macrophages, which exist in the front line receiving environmental information, have an important function in forming a macrophage network for biophylaxis. In this review, we introduce intestinal macrophages as an example of the highly plastic and flexible cells adaptable to environmental information. Intestinal macrophages are hyporesponsiveness to foreign substances, especially lipopolysaccharide (LPS), and less expression of CD14 and TLR4/MD-2, receptors for LPS. However, those proteins expression was observed in the cytoplasm of intestinal macrophage. We also found that intestinal macrophages treated with IgA could restore in response to LPS. |
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