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 书籍（章节） Blood–Brain Barrier as a Point of Concern for Neural Drug Delivery 相关领域
血脑屏障
药物输送
药品
药物输送到大脑
神经科学
医学
计算机科学
药理学
纳米技术
心理学
材料科学
中枢神经系统
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Problems and Advancements ， ABSTRACT The blood–brain barrier (BBB) is a selectively permeable protective membrane that primarily prevents the entry of pathogens and toxins to the central nervous system (CNS). This barrier also prevents the delivery of most therapeutic pharmaceuticals, particularly with a molecular weight greater than 400 Da, leading to inadequate drug delivery into the brain. Under such circumstances, less efficacy and fewer side effects appear due to the accumulation of the drug in non-targeted organs and tissues. However, based on the mechanism of endogenous transport within the BBB, certain drugs can be restructured for efficient delivery. |
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