| 标题 |
 Triton CG-110 as an alternative for cell lysis in manufacturing of adeno-associated virus-based gene therapy 相关领域
Triton X-100
溶解
化学
色谱法
肺表面活性物质
生物化学
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| 网址 | |
| DOI | |
| 其它 | Triton X-100 is one of the most widely used detergents for cell lysis in gene therapy product manufacturing. However, due to the aquatic toxicity of the degradation product, Triton X-100 is regulated by the European Chemical Agency as a substance of very high concern. In this study, we aim to identify eco-friendly detergent alternatives to replace Triton X-100. Tween 20, Tween 80, n-Dodecyl-β-D-maltoside (DDM), and Triton CG-110 were tested and compared with Triton X-100. Triton CG-110 demonstrated similar performance during the harvest and subsequent purification process for multiple AAV vectors at different scales. Therefore, Triton CG-110 represents an effective and environmentally safe detergent alternative to Triton X-100. |
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(2025-6-4)
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