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Emodin mediated down regulation of matrix metalloproteinases (MMPs) in SNP treated colon cancer cells
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Umadevi, D.; Uma, C. The degree of over expression of MMP2 and MMP9 (gelatinases A and B) has been noted to correlate with the stages of disease or prognosis and demonstrated early in the transition from colon adenoma to adinocarcinoma. Elevated levels of distinct MMPs detected in tumor tissue or serum of patients with advanced cancer and they are the major prognostic indicators in cancer. Inhibition of MMPs has been explored as a therapeutic goal for almost two decades. Nitric oxide (NO), a free radical plays an important role in signaling pathways regulate MMP expression. MMPs are under the control of NO system. The present study demonstrated the role of exogenous NO levels in the regulation of MMP 2 and 9 in colon cancer cell line WiDr and its inhibition with emodin (a naturally occurring anthraquinone). © 2010 RJPBCS. |
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(2025-6-4)
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