| 标题 |
 Pathophysiology of Gastroesophageal Reflux Disease in Obese Patients |
| 备注 |
First Online: 26 June 2025 作者Marco G. Patti, Francisco Schlottmann & Fernando A. M. Herbella
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Abstract Gastroesophageal reflux disease (GERD) and obesity coexist in many patients. The association is not coincidental, since obesity plays a major role in the pathophysiology of GERD. Obesity is associated with a higher number of transient lower esophageal sphincter relaxations and abnormal peristalsis. Central obesity increases the trans-diaphragmatic pressure gradient and disrupts the anatomy of the gastroesophageal junction by causing hiatal hernia formation. Sleeve gastrectomy influences GERD pathophysiology. |
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(2025-6-4)
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