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Chapter 23 - Nematode C. elegans: Genetic Dissection of Pathways Regulating Seizure and Epileptic-Like Behaviors
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The past decade has seen increasing reports on genetic variants associated with human diseases. Determining the causality of such variants requires better understanding of the functions of disease-associated genes. Researches conducted using the nematode Caenorhabditis elegans have had tremendous impact in the discovery of fundamental mechanisms underlying the development and function of the nervous system. This chapter focuses on studies relevant to the overarching goals in the investigation of causes and cures in seizure and epilepsy. Many genes implicated in seizure or epilepsy in humans are conserved in C. elegans. Genetic dissection of seizure or epilepsy-like phenotypes in C. elegans .https://doi.org/10.1016/B978-0-12-804066-9.00023-7 |
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