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Immune checkpoint blockade (ICB) has improved the management of NSCLC, but only a minority of patients respond and long-lasting remissions are rare. In contrast to findings in other cancers, Martinez-Usatorre et al. report that combining ICB (PD1 antibodies) with antiangiogenic therapy (ANGPT2 and VEGFA blockade) is not beneficial in mouse models of NSCLC. Antiangiogenic therapy increased tumour infiltration by PD1+ Treg cells, which was sustained by tumour-associated macrophages (TAMs) and targeted by PD1 antibodies. Depleting TAMs — using a CSF1R inhibitor and cisplatin — redirected PD1 antibodies to CD8+ T cells, magnifying the tumour response to antiangiogenic immunotherapy.

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