透皮
角质层
医学
药物输送
渗透(战争)
药品管理局
药品
药理学
皮肤屏障
超声波
输送系统
生物医学工程
纳米技术
皮肤病科
材料科学
病理
工程类
放射科
运筹学
作者
Aharon Azagury,Luai R. Khoury,Giora Enden,Joseph Kost
标识
DOI:10.1016/j.addr.2014.01.007
摘要
Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injections. However, the stratum corneum serves as a barrier that limits the penetration of substances to the skin. Application of ultrasound (US) irradiation to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. This review presents the main findings in the field of sonophoresis in transdermal drug delivery as well as transdermal monitoring and the mathematical models associated with this field. Particular attention is paid to the proposed enhancement mechanisms and future trends in the fields of cutaneous vaccination and gene therapy.
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