生物相容性
光热治疗
药物输送
咪唑酯
化学
体内
癌症研究
纳米技术
医学
材料科学
有机化学
生物
生物技术
作者
Qinglian Hu,Liwang Xu,Xiaoyu Huang,Yuxuan Duan,Dongchang Sun,Zhengwei Fu,Yunfen Ge
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2023-11-08
卷期号:24 (12): 5964-5976
被引量:2
标识
DOI:10.1021/acs.biomac.3c00971
摘要
Metal–organic frameworks (MOFs) are promising drug-delivering platforms for their intrinsic capability of loading and releasing different cargoes. To further extend their biomedical practices, the development of collaborative MOF systems with good biocompatibility and synergistic efficacy is essential. Herein, the near-infrared and pH dual-response collaborative zeolitic imidazolate framework-8 (ZIF-8) platform SOR@ZIF-8@PDA (SZP) was constructed, in which the chemotherapeutic drug sorafenib (SOR) was encapsulated in ZIF-8 and via polydopamine (PDA) coating on ZIF-8 by hierarchical self-assembly. PDA coating serves as a photothermal agent for PPT while reducing the toxicity of ZIF-8. SZP achieves intelligent release of therapeutic drugs by responding to the lower pH of the tumor microenvironment and thermal stimulation generated by near-infrared light irradiation. In addition, under light irradiation, SZP could effectively realize treatment of cancer cells through synergistic chemo-photothermal therapy, as evidenced by the enhanced cell apoptosis, inhibited tumor cell proliferation and migration. This collaborative MOFs system showed excellent biocompatibility and antitumor ability in vivo on a mouse HepG2 tumor model. Our results demonstrated that PDA-modified MOFs exhibited a fantastic good development prospect in biomedical applications.
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