A snake cathelicidin enhances transcription factor EB‐mediated autophagy and alleviates ROS‐induced pyroptosis after ischaemia–reperfusion injury of island skin flaps

Ischaemia-reperfusion (I/R) injury is a major contributor to skin flap necrosis, which presents a challenge in achieving satisfactory therapeutic outcomes. Previous studies showed that cathelicidin-BF (BF-30) protects tissues from I/R injury. In this investigation, BF-30 was synthesized and its role and mechanism in promoting survival of I/R-injured skin flaps explored.