Influence of depressive disorders on quality of life and three-year survival of patients with coronary heart disease

Abstract Background/Introduction Depressive disorders (DD) affect more than 350 million people in the general population, especially among patients with cardiovascular diseases. World Health Organization predicts that by 2030 coronary heart disease (CHD) and DD will become the leading causes of disability in the civilized countries of the world. This fact indicates the need to identify DR at the early stages of examination of patients with CHD for timely correction and improvement of prognosis. Purpose of the work To assess the quality of life and three-year survival rate of patients with CHD in combination with DR. Methods 122 patients with chronic CHD (with exertional angina of II-III functional classes) were included in the study on the basis of the cardiology department. The presence and level of depression, anxiety, and social adaptation were assessed using the Beck Depression Scales (BDI), Sheehan Anxiety (ShARS), Social Adaptation (Bosc). The three-year survival rate was also investigated. Two groups were formed: the first – 58 patients with CHD with DD and the second – 64 patients with CHD without DD. Data were presented as M ± SD. The difference was considered statistically significant at p<0.05. The 3-year survival rate of patients was assessed using the Kaplan-Meier method with the determination of differences between groups using the Wilcoxon-Gehan test. Results The groups were comparable in terms of the main clinical and demographic characteristics and concomitant therapy. In patients with depression, compared with patients without it, was identified an increased level of depression (BDI – 7.3±4.3 points vs 2.3±1.6 points, p=0.ehab724.275201) and anxiety (Shikhana – 37.6±20.3 points vs 18.3±12.4 points, p=0.0002); lower level of social functioning (Bosc – 35.0±7.3 points vs 39.3±5.8 points, p=0.04). The 3-year survival rate was 92.6% (113 people), of which in the first group – 87.9% (51 people), in the second – 96.9% (62 people). The worst survival rate (Gehan-Wilcoxon test, p=0.03) was noted in the group of CHD with DD. Conclusion(s) In patients with chronic CHD in combination with DD, an increased level of anxiety and a lower quality of life were revealed, which can worsen the course of CHD. The 3-year survival rate is significantly worse in patients with CHD with a DD in comparison with patients without mental disorders. Funding Acknowledgement Type of funding sources: None.