氧化还原
化学
离子运输机
渗透
离子
离子通道
生物物理学
组合化学
光化学
膜
无机化学
有机化学
生物化学
受体
生物
作者
Linlin Shi,Zhenhai Wen,Zhihui Jiu,Jingjing Guo,Qingyuan Zhu,Yonghui Sun,Bo Zhu,Junbiao Chang,Pengyang Xin
标识
DOI:10.1002/ange.202403667
摘要
Abstract Natural redox‐regulated channel proteins often utilize disulfide bonds as redox sensors for adaptive regulation of channel conformations in response to diverse physiological environments. In this study, we developed novel synthetic ion channels capable of reversibly switching their ion‐transport capabilities by incorporating multiple disulfide bonds into artificial systems. X‐ray structural analysis and electrophysiological experiments demonstrated that these disulfide‐bridged molecules possess well‐defined tubular cavities and can be efficiently inserted into lipid bilayers to form artificial ion channels. More importantly, the disulfide bonds in these molecules serve as redox‐tunable switches to regulate the formation and disruption of ion‐permeation pathways, thereby achieving a transition in the transmembrane transport process between the ON and OFF states.
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