Single‐cell and spatial transcriptomics reveal POSTN+ cancer‐associated fibroblasts correlated with immune suppression and tumour progression in non‐small cell lung cancer

Our study identified a myofibroblastic CAF subpopulation, POSTN⁺ CAFs, which might associate with SPP1⁺ macrophages to promote the formation of desmoplastic architecture and participate in immune suppression. Furthermore, we showed that POSTN⁺ CAFs associated with cancer progression and poor clinical outcomes and may provide new insights on the treatment of NSCLC.