纳米复合材料
活力测定
石墨烯
纳米材料
材料科学
生物相容性材料
纳米技术
氧化物
纳米颗粒
癌症研究
生物物理学
生物医学工程
细胞
化学
医学
生物化学
生物
冶金
作者
Melissa Silva Monteiro,Marina Mesquita Simões,L. M. Garcı́a,Paulo Roberto Santos,Carolina Viveiros,Ronei Delfino da Fonseca,Michelle da Cunha Abreu Xavier,Gabriel Ws de Mendonça,Suélia de Siqueira Rodrigues Fleury Rosa,S. Silva,Leonardo G. Paterno,P. C. Morais,Sônia Nair Báo
出处
期刊:Nanomedicine
日期:2023-12-19
标识
DOI:10.2217/nnm-2023-0312
摘要
Aim: This report proposes using the Hill model to assess the benchmark dose, the 50% lethal dose, the cooperativity and the dissociation constant while analyzing cell viability data using nanomaterials to evaluate the antitumor potential while combined with radiofrequency therapy. Materials & methods: A nanocomposite was synthesized (graphene oxide-polyethyleneimine-gold) and the viability was evaluated using two tumor cell lines, namely LLC-WRC-256 and B16-F10. Results: Our findings demonstrated that while the nanocomposite is biocompatible against the LLC-WRC-256 and B16-F10 cancer cell lines in the absence of radiofrequency, the application of radiofrequency enhances the cell toxicity by orders of magnitude. Conclusion: This result points to prospective studies with the tested cell lines using tumor animal models.
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