Radioactive hydrogel with NETs degradation capacity for the boosted tumor radio-immunotherapy

I-CMCSMA/DNase I gel effectively inhibited both primary and distant tumor growth. Therefore, this approach realizes efficient radio-immunotherapy of tumors by attaching the therapeutic radioisotope to hydrogel scaffolds and combining radiotherapy with a NETs-degrading enzyme, providing a novel strategy to enhance radioisotopes-stimulated immunotherapy.