Iodine(III) Promoted Umpolung Cyclization of Thio/Seleno‐Urea With Enaminones: Preparation of 2‐Amino‐5‐acyl‐thiazoles/Selenazoles via C─N Bond Cleavage

ABSTRACT A hypervalent iodine‐mediated one‐step general method for the preparation of 2‐amino‐5‐acyl‐thiazoles and selenazoles has been disclosed. The reactions progress via umpolung cyclization of thio/seleno‐urea with enaminones. Mechanistically, the reaction progresses via C─N bond cleavage of enaminones rather than C═C bond.