化学
炔烃
腈
烯烃
催化作用
酰胺
氢化物
呋喃
阳离子聚合
铋
硅烷
组合化学
反应机理
芳基
有机化学
药物化学
高分子化学
氢
烷基
作者
Xiuxiu Yang,Jennifer Kuziola,Vanessa A Béland,Julia Busch,Markus Leutzsch,Jordi Bures,Josep Cornella
标识
DOI:10.1002/anie.202306447
摘要
In this article we report that a cationic version of Akiba's Bi(III) complex catalyzes the reduction of amides to amines using silane as hydride donor. The catalytic system features low catalyst loadings and mild conditions, en route to secondary and tertiary aryl- and alkylamines. The system permits that functional groups such as alkene, alkyne, ester, nitrile, furan, and thiophene remain intact. Kinetic studies on the reaction mechanism result in the identification of a reaction network with an important product inhibition that is in agreement with the experimental reaction profiles.
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