化学
芳构化
环加成
串联
组合化学
铑
催化作用
有机化学
立体化学
复合材料
材料科学
作者
Sujin Min,Tae‐Eun Kim,Taejoo Jeong,Joon‐Young Yang,Yoon Seok Oh,Kyeongwon Moon,Amitava Rakshit,In Su Kim
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-06-07
卷期号:25 (23): 4298-4302
被引量:7
标识
DOI:10.1021/acs.orglett.3c01336
摘要
The synthesis of functionalized carbazoles as privileged nitrogen heterocycles has emerged as a central topic in drug discovery and material science. We herein disclose the rhodium(III)-catalyzed cross-coupling reaction between indolyl nitrones and 2-methylidene cyclic carbonate as an allylating surrogate, resulting in the formation of C2-formylated carbazoles via tandem C–H allylation, [3 + 2] cycloaddition, aromatization, and benzylic oxidation. The synthetic utility of this protocol is highlighted by a variety of post-transformations of C2-formylated carbazoles.
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