化学
酮
戒指(化学)
二硒醚
烯酮
反应条件
药物化学
有机化学
组合化学
催化作用
硒
作者
Jun Yao,Dandan Hu,Jun-Qi Zhang,Yili Zhang,Xinyi Ma,Jiang Liu,Jiali Wang,Bukuo Ni,Hongjun Ren
标识
DOI:10.1021/acs.joc.2c02004
摘要
Ring opening of cycloalkanols has been employed as a commonly used strategy to prepare diverse distal functionalized ketones. However, most of these ketones obtained by this strategy belong to monofunctional ketones, while difunctional ketones with more potential application value have been rarely reported. Herein, we first reported a mild I2-promoted ring-opening selenation of cyclopropanol to synthesize various distal difunctional ketones. In the reaction, hydroxyl (-OH) derived from water and RSe+ from diselenide can be introduced into the α- and β-positions, respectively, delivering β-hydroxy selenylated ketones in good to excellent yields.
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