内皮
机械敏感通道
炎症
内皮功能障碍
血管舒张
医学
神经科学
血流动力学
肺动脉高压
生物
受体
细胞生物学
生物信息学
心脏病学
内科学
离子通道
作者
Margherita Tiezzi,Hanqiang Deng,Nicolas Baeyens
标识
DOI:10.1016/j.bcp.2022.115290
摘要
The endothelium is a mechanosensitive organ whose pleiotropic actions regulate vessel structure to adjust tissue perfusion. To do so, it possesses ion channels, receptor complexes, and signaling pathways responding to blood flow, whose activation will either maintain vascular integrity and quiescence or, on the contrary, remodel the vessel's structure in both health and disease. Recent studies have demonstrated the crucial role of endothelial inflammation, endothelial to mesenchymal transition (EndMT), and perturbed hemodynamics in the progression of pulmonary arterial hypertension and essential hypertension. These two distinct diseases share some common mechanistic cues, pointing towards new potential therapeutic approaches to treat them. In this review, we summarize these common mechanisms to map future drug development strategies targeting flow sensing mechanisms and vascular remodeling.
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