斑马鱼
生物
甲状腺
激素
基因沉默
谱系(遗传)
模式生物
神经科学
生物信息学
基因
内分泌学
遗传学
作者
Iván Lazcano,Santiago Pech-Pool,Arturo Olverá,I. García-Martínez,S. Palacios-Pérez,Aurea Orozco
标识
DOI:10.1016/j.ygcen.2023.114225
摘要
The zebrafish is an optimal experimental model to study thyroid hormone (TH) involvement in vertebrate development. The use of state-of-the-art zebrafish genetic tools available for the study of the effect of gene silencing, cell fate decisions and cell lineage differentiation have contributed to a more insightful comprehension of molecular, cellular, and tissue-specific TH actions. In contrast to intrauterine development, extrauterine embryogenesis observed in zebrafish has facilitated a more detailed study of the development of the hypothalamic-pituitary-thyroid axis. This model has also enabled a more insightful analysis of TH molecular actions upon the organization and function of the brain, the retina, the heart, and the immune system. Consequently, zebrafish has become a trendy model to address paradigms of TH-related functional and biomedical importance. We here compilate the available knowledge regarding zebrafish developmental events for which specific components of TH signaling are essential.
科研通智能强力驱动
Strongly Powered by AbleSci AI