Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions

全基因组关联研究卵巢癌单核苷酸多态性计算生物学生物上皮性卵巢癌生物信息学肿瘤科癌症遗传学内科学医学基因型基因

作者

Eileen Dareng,Simon G. Coetzee,Jonathan Tyrer,Pei-Chen Peng,Will Rosenow,Stephanie Chen,Brian Davis,Felipe Segato Dezem,Ji-Heui Seo,Robbin Nameki,Alberto Luiz P. Reyes,Katja K.H. Aben,Hoda Anton‐Culver,Natalia Antonenkova,Gerasimos Aravantinos,Elisa V. Bandera,Laura E. Beane Freeman,Matthias W. Beckmann,Alicia Beeghly‐Fadiel,Javier Benı́tez,Marcus Q. Bernardini,Line Bjørge,Amanda Black,Natalia Bogdanova,Kelly L. Bolton,James D. Brenton,Agnieszka Budziłowska,Ralf Bützow,Hui Cai,Ian Campbell,Rikki A. Cannioto,Jenny Chang‐Claude,Stephen J. Chanock,Kexin Chen,Georgia Chenevix‐Trench,Yoke-Eng Chiew,Linda S. Cook,Anna deFazio,Joe Dennis,Jennifer A. Doherty,Thilo Dörk,Andreas du Bois,Matthias Dürst,Diana Eccles,Gabrielle Ene,Peter A. Fasching,James M. Flanagan,Renée T. Fortner,Florentia Fostira,Aleksandra Gentry‐Maharaj,Graham G. Giles,Marc T. Goodman,Jacek Gronwald,Christopher A. Haiman,Niclas Håkansson,Florian Heitz,Michelle A.T. Hildebrandt,Estrid Høgdall,Claus Høgdall,Ruea‐Yea Huang,Allan Jensen,Michael E. Jones,Daehee Kang,Beth Y. Karlan,Anthony N. Karnezis,Linda E. Kelemen,Catherine J. Kennedy,Э. К. Хуснутдинова,Lambertus A. Kiemeney,Susanne K. Kjær,Jolanta Kupryjańczyk,Marilyne Labrie,Diether Lambrechts,Melissa C. Larson,Nhu D. Le,Jenny Lester,Li Lian,Jan Lubiński,Michael Lush,Jeffrey R. Marks,Keitaro Matsuo,Taymaa May,Esther M. John,Iain A. McNeish,Usha Menon,Stacey A. Missmer,Francesmary Modugno,Melissa Moffitt,Álvaro N.A. Monteiro,Kirsten B. Moysich,Steven A. Narod,Tú Nguyen‐Dumont,Kunle Odunsi,Håkan Olsson,N. Charlotte Onland‐Moret,Sue K. Park,Tanja Pejović,Jennifer B. Permuth,Anna Piskorz,Darya Prokofyeva,Marjorie J. Riggan,Harvey A. Risch,Cristina Rodríguez‐Antona,Mary Anne Rossing,Dale P. Sandler,V. Wendy Setiawan,Kang Shan,Honglin Song,Melissa C. Southey,Helen Steed,Rebecca Sutphen,Anthony J. Swerdlow,Soo‐Hwang Teo,Kathryn L. Terry,Pamela J. Thompson,Liv Cecilie Vestrheim Thomsen,Linda Titus,Britton Trabert,Ruth C. Travis,Shelley S. Tworoger,Ellen Valen,Els Van Nieuwenhuysen,Digna Velez Edwards,Robert A. Vierkant,Penelope M. Webb,Clarice R. Weinberg,R Weise,Nicolas Wentzensen,Emily White,Stacey J. Winham,Alicja Wolk,Yin Ling Woo,Anna H. Wu,Yan Li,Drakoulis Yannoukakos,Nur Zeinomar,Wei Zheng,Argyrios Ziogas,Andrew Berchuck,Ellen L. Goode,David G. Huntsman,Celeste Leigh Pearce,Susan J. Ramus,Thomas A. Sellers,Matthew L. Freedman,Kate Lawrenson,Joellen M. Schildkraut,Dennis J. Hazelett,Jasmine Plummer,Siddhartha Kar,Michelle R. Jones,Paul D.P. Pharoah,Simon A. Gayther

出处

期刊：American Journal of Human Genetics [Elsevier]
日期：2024-05-08 卷期号：111 (6): 1061-1083 被引量：2

链接

nih.govdoi.org

标识

DOI：10.1016/j.ajhg.2024.04.011

摘要

To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases and 105,724 controls of European origin. We identified five histotype-specific EOC risk regions (p value <5 × 10

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Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions

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