From Anabolic to Oxidative

In Brief Interleukin 15 (IL-15) and its receptor IL-15 receptor-α (IL-15Rα) are suggested to function in the determination of skeletal muscle phenotypes, with IL-15 originally proposed as an anabolic cytokine. This review will focus on recent work demonstrating that manipulation of IL-15 and IL-15Rα in vivo promotes changes in exercise capacity, muscle fatigue, and gene expression indicative of a more oxidative skeletal muscle phenotype. Manipulation of IL-15 and IL-15Rα in vivo promotes a more oxidative skeletal muscle phenotype.